(a) CSF
(b) Plasma
Figure 7: Comparison on the chromatograms at m/z 593.5 for one CSF sample (a) or one plasma sample (b) processed for F2-IsoPs analysis that has been used in Figure 4 without (left panel) and with (right panel) additional 30-min holding of the column at 280°C at the end of data acquisition. The range of retention time corresponding to that for F4-NPs quantification is indicated by the braces although these samples were not used for F4-NPs quantification.