Neuroprotective Effect of Ginseng against Alteration of Calcium Binding Proteins Immunoreactivity in the Mice Hippocampus after Radiofrequency Exposure
Figure 5
Photomicrograph of calretinin (CR) immunoreactivity (IR) in coronal sections through the hippocampal subfields of sham control (SC) (a, d, g), radiofrequency-exposed (E1.6) (b, e, h), and ginseng-treated (G1.6) (c, f, i) groups. CA1 area consisted of strong CR immunoreactive neurons in SO and SLM along with thin immunoreactive fibers. Severe loss of neuronal staining as well as CR IR was noted in the CA1 of E1.6 (b). Intense CR IR was detected in the IML with highly stained infragranular neurons (d–f). Intensely labeled immunoreactive fibers with few neurons appeared to be present in the CA3 area. Severe decrease of IR was noted in the E1.6 (h) as compared with SC (g) and G1.6 (i). SO: stratum oriens; SP: stratum pyramidale; SR: stratum radiatum; SLM: stratum lacunosum moleculare; SL: stratum lucidum; OML: outer molecular layer; IML: inner molecular layer; GL: granular layer; PL: polymorphic layer. Scale bar = 100 μm.
