Phytoestrogen <i>α</i>-Zearalanol Attenuates Homocysteine-Induced Apoptosis in Human Umbilical Vein Endothelial Cells

<table>Pretreatment with <i>α</i>-ZAL enhanced the expression of prosurvival protein Bcl-2 in homocysteine-challenged HUVECs (immunohistochemistry staining, only showing the picture of the highest concentration 10<sup>−6</sup> mol/L). The expression of prosurvival protein Bcl-2 was significantly decreased after treatment with 500 <i>μ</i>mol/L homocysteine for 24 h. Pretreatment with <i>α</i>-ZAL could enhance the expression of Bcl-2. Data were presented as mean ± SD. <svg height="13.95" id="M14" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 66.324997 13.95" width="66.324997" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> versus Hcy alone. <i>α</i>-ZAL: <i>α</i>-zearalanol; 17<i>β</i>-E<sub>2</sub>: 17<i>β</i>-estradiol; Hcy: homocysteine.</table>

BioMed Research International

fig7

Figure 7

Figure 7: Phytoestrogen <i>α</i>-Zearalanol Attenuates Homocysteine-Induced Apoptosis in Human Umbilical Vein Endothelial Cells 

BioMed Research International

Phytoestrogen α-Zearalanol Attenuates Homocysteine-Induced Apoptosis in Human Umbilical Vein Endothelial Cells

Figure 7