Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

Figure 7

Effect of interaction between alginate and Acrycoat E30D on experimental variables represented in 3D response curves.

(a) Effect of interaction between alginate and Acrycoat E30D on zero-order rate constant (𝐾₀) represented in 3D response curve

(b) Effect of interaction between alginate and Acrycoat E30D on the amount of drug released in 120 minutes (2 hr) 𝑋₁₂₀, represented in 3D response curve

(c) Effect of interaction between alginate and Acrycoat E30D on time of 80% drug release (𝑡₈₀) represented in 3D response curve

(d) Effect of interaction between alginate and Acrycoat E30D on the diffusion coefficient (𝑛) represented in 3D Response curve