Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide
Table 1
Design summary of experimental design.
(a)
Study type
Initial design
Center points
Design model
Runs
Blocks
Factorial
Full Factorial
0
2FI
9
No Blocks
(b)
Factor
Name
Units
Type
Low Actual
High Actual
Levels
Alginate
%w/w
Categoric
1%
4%
3
Acrycoat E30D
%w/w
Categoric
0%
4%
3
(c)
Response
Name
Units
Observn.
Analysis
Min.
Max.
Mean
SD
Ratio
Y1
mg/hr
9
Factorial
8.89
11.47
10.64
0.82
1.29
Y2
mg
9
Factorial
8.00
37.34
22.51
10.7
4.67
Y3
hr
9
Factorial
4.50
9.30
7.12
1.47
2.07
Y4
ā
9
Factorial
0.60
1.79
1.01
0.37
3.00
The design matrix Evaluation for factorial 2FI model. Degrees of freedom (dF) for evaluation, model: 8, residuals: 0, lack of fit: 0, pure error: 0, and total: 9.