Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

Table 3

Evaluation result of physicochemical parameter of frusemide calcium alginate micropellets.

Formulation code	Mean diameter*	Angle of repose (θ)**	% Moisture content**	Drug entrapment efficiency (%)**	LSC (%) with respect to gross wt. of the micropellets	LSC (%) with respect to entrapped drug	Disintegration time (min)**
	(µm ± SD)
F1	608.14±0.39	16.76±0.54	1.71±0.81	95.94±0.63	2.271	2.367	24±4.53
F2	655.90±1.03	18.06±0.96	1.59±0.76	99.02±0.82	1.943	1.962	36±5.21
F3	694.85±0.72	20.11±0.88	1.97±0.32	99.47±0.91	1.677	1.686	52±4.68
F4	608.16±0.59	18.32±0.79	1.48±0.48	94.48±0.48	3.353	3.549	42±3.85
F5	760.89±0.51	20.56±1.03	1.44±0.56	93.44±0.56	2.214	2.369	64±6.11
F6	782.78±0.36	21.24±1.97	2.23±0.68	91.23±0.68	1.429	1.567	97±4.37
F7	632.1±0.73	19.52±1.21	1.67±0.33	96.21±0.37	1.882	1.956	73±5.24
F8	693.36±0.56	21.39±1.07	1.42±0.54	97.76±0.56	0.913	0.729	115±5.98
F9	841.65±0.48	22.56±0.77	2.32±0.64	98.37±0.77	0.594	0.604	>120

∗Results shown are “mean ± SD,” 𝑛 = 6 for mean diameter; signifies value < 0.01%. **Results shown are “mean ± SD,” 𝑛=3.