Formulation and Mathematical Optimization of Controlled Release Calcium Alginate Micro Pellets of Frusemide

Table 9

Flame photometry mean readings of sodium and potassium ions in urine sample from Groups C, S, and T after 5 and 24 hours.

Sl. no.	Group	Treatment	Na+ ion		K+ ion
			5th hour	24th hour	5th hour	24th hour
1; 2; 3; 4; 5	Control; (C)	Normal saline; 5 mL/100 g body wt.	24	28	21	11
6; 7; 8; 9; 10	Standard; (S)	Pure frusemide 50 mg/kg; p.o.	69	44	25	14
11; 12; 13; 14; 15	Test; (T)	Frusemide micropellets; 50 mg/kg p.o.	74	67*	30	27*

Values are expressed ± SEM
“∗”Indicates (𝑃<0.05), 𝑛=5.