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BioMed Research International
Volume 2013 (2013), Article ID 821310, 11 pages
Review Article

Tumor Necrosis Factor Receptor 2: Its Contribution to Acute Cellular Rejection and Clear Cell Renal Carcinoma

1Department of Nephrology, First Hospital of China Medical University, Shenyang, China
2Department of Medicine, Cambridge University NHS Trust Hospitals, Addenbrooke’s Hospital, P.O. Box 157, Level 5, Hill’s Road, Cambridge CB2 0QQ, UK

Received 25 August 2013; Revised 15 October 2013; Accepted 17 October 2013

Academic Editor: Shin Maeda

Copyright © 2013 Jun Wang and Rafia S. Al-Lamki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Tumor necrosis factor receptor 2 (TNFR2) is a type I transmembrane glycoprotein and one of the two receptors that orchestrate the complex biological functions of tumor necrosis factor (TNF, also designed TNF-α). Accumulating experimental evidence suggests that TNFR2 plays an important role in renal disorders associated with acute cellular rejection and clear cell renal carcinoma but its exact role in these settings is still not completely understood. This papers reviews the factors that may mediate TNFR2 induction in acute cellular rejection and clear cell renal carcinoma and its contribution to these conditions and discusses its therapeutic implications. A greater understanding of the function of TNFR2 may lead to the development of new anti-TNF drugs.