Analgesic and Anti-Inflammatory Activities of the Methanolic Stem Bark Extract of Nyctanthes arbor-tristis Linn.

Table 5

Rate of edema formation.

Group	Dose (mg/kg)	Increase in edema (%)
		0 hr	1 hr	2 hr	3 hr	4 hr	5 hr
Control	—	—	36.25 ± 0.11	77.32 ± 0.14	96.43 ± 0.43	103.14 ± 0.13	100.41 ± 0.23
Standard	100 (p.o)	—	18.34 ± 0.34 a^#	31.12 ± 0.16 a^#	37.14 ± 0.41 a^#	27.34 ± 0.45 a^#	19.32 ± 0.34 a^#
MENA250	250 (p.o)	—	25.12 ± 0.16 a^#b^@	51.26 ± 0.13 a^#b^@	62.32 ± 0.32 a^#b^@	56.57 ± 0.22 a^#b^@	48.43 ± 0.21 a^#b^@
MENA500	500 (p.o)	—	27.45 ± 0.17 a^#b^@c^@	47.32 ± 0.14 a^#b^@c^@	55.31 ± 0.43 a^#b^@c^@	45.42 ± 0.20 a^#b^@c^@	34.21 ± 0.24 a^#b^@c^@

Data are expressed as Mean ± SEM, 𝑛=6 animals in each group. One-way ANOVA was carried out using Turkey’s multiple comparison tests. Comparisons were made between:
a: Control versus Standard, MENA₂₅₀, and MENA₅₀₀.
b: Standard versus MENA₂₅₀ and MENA₅₀₀.
c: MENA₂₅₀ versus MENA₅₀₀.
Symbols represent statistical significance: *𝑃<0.05, ^#𝑃<0.01, ^@𝑃<0.001, ns: nonsignificant.