Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model
Figure 2
Histological cardiac sections from Beagle dogs DNA-immunized and infected with Ninoa strain of T. cruzi. Representative micrographs are shown. (a) Score 1 (1 or less foci of inflammatory cells/field) from a dog immunized with TcSSP4 gene (pBCSSP4 plasmid); (b) score 2 (>1 inflammatory foci/field) from a dog immunized with TcSP gene (pBCSP plasmid); (c) score 3 (generalized coalescing of foci of inflammation or disseminated inflammation with minimal cell necrosis and retention of tissue integrity) from a dog mock-immunized with SS, and (d) score 0 (without foci of inflammation) from a healthy/uninfected dog. Hematoxylin and eosin stain; 10x magnification.
