Effect of the Plasmid-DNA Vaccination on Macroscopic and Microscopic Damage Caused by the Experimental Chronic Trypanosoma cruzi Infection in the Canine Model

Table 3

Inflammatory lesion (lymphocyte infiltrates) scores from three different sections of heart tissues of DNA-immunized dogs with chronic experimental Chagas disease.

Site	TcSP gene; (pBCSP plasmid)	TcSSP4 gene; (pBCSSP4 plasmid)	pBK-CMV; (empty plasmid)	SS; (mock-immunized)
Subepicardium	0.800±0.2^∗	0.99±0.4^∗	1.0714±0.4^∗	1.0±0.0^∗
Myocardium	0.7429±0.1^∗	0.5143±0.1	0.7143±0.4^∗	0.9429±0.4^∗
Subendocardium	0.1429±0.03	0.2857±0.04	0.7143±0.4^∗	0.8932.3^∗

∗Differences were considered as significant when 𝑃≤0.05 (Kruskal-Wallis test among immunized/infected and healthy non-infected control animals, whose values obtained were 0.0, was performed).