Development of a Novel System for Mass Spectrometric Analysis of Cancer-Associated Fucosylation in Plasma α1-Acid Glycoprotein
Mass spectra of methylated forms of AGP glycans derived from methyl esterification of sialylated glycans during the labeling process. Several de- (M−) and over- (M+) methylated glycans were detected around the exact labeled glycans. Purified AGP was prepared and labeled from 500 μL of plasma sample and an aliquot (ca. one-fiftieth) was used for MS analysis. See the details in the text.
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