Modeling of the Renal Kinetics of the AT1 Receptor Specific PET Radioligand [11C]KR31173
Figure 2
Compartmental model. The rate constants and represent binding to and release from nonspecific binding sites. The rate constants and represent binding to and release from specific binding sites. With the proposed parallel connectivity model, the distribution volume of binding is , where is total distribution volume, is distribution volume of specific binding, and DVNS is distribution volume of nonspecific binding. Each DV is represented by the area under curve of the corresponding component of the impulse response function (/ versus /).
