Modeling of the Renal Kinetics of the AT1 Receptor Specific PET Radioligand [¹¹C]KR31173

Figure 4

Examples of digital autoradiography (a) and a PET scan (b). Digital autoradiography shows clear distinction between cortex and medulla. Although radioligand binding in the medulla is higher than that in the cortex, a cortical ROI was used for data analysis to correlate in vitro binding with in vivo cortical binding. The PET scan represents an axial summed image between 30 and 60 minutes after injection. There was no difference between [¹¹C]KR31173 binding in the left kidney after IR (LK) and the contralateral right kidney (RK).

(a)

(b)