Presymptomatic Treatment with Acetylcholinesterase Antisense Oligonucleotides Prolongs Survival in ALS (G93A-SOD1) Mice
Figure 1
Presymptomatic mEN101 treatment delays death in the Tg-mice when compared to normal saline (NS), neostigmine (Neo), and inverse mEN101 (INV). Cumulative probability of death was delayed by mEN101. The mean time to death was significantly prolonged by 9 days in animals treated with mEN101 () compared to NS () () and by 15 days when compared to Neo () (). No significant effect on survival was found in the Inv () or Neo () treated groups when compared to NS although a nonsignificant trend towards earlier death was seen in the Neo group.
