Research Article

Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-β Knockout Mice

Figure 4

High-magnification photomicrographs of the Otx2-labeled sections in the control (a) and KO (b) mice. (a, b) Photomicrographs in the superficial (A) and deep main (B) layers of the SC. Note that the darklylabeled small-to-medium cells are densely distributed in the superficial layers in the SC of the control mouse. Similar patterns of distribution of Otx2-IR cells are also observed in the KO mice, but fewer Otx2-IR cells are observed in the KO mice. Scale bar = 60 μm. (C) Higher-magnification photomicrographs of the Otx2-IR cells in the optic (OP) layer. Note oval- or round-shaped Otx2-IR cells. IRelements are localized in the nucleus of the cell body. Orientation of the images is dorsal to the top and lateral to the left. Scale bar = 10 μm.
(a)   Control (Otx2)
(b) KO (Otx2)