Integration of Data from Omic Studies with the Literature-Based Discovery towards Identification of Novel Treatments for Neovascularization in Diabetic Retinopathy

Table 5

Pharmacological substances affecting the main biological pathways found dysregulated in diabetic retinopathy models by transcriptional profiling in disease.

Substance	Semantic relation	Process	Frequency
Curcumin	Disrupts	Cell proliferation	69
Endostatins	Inhibits	Angiogenesis	69
Tretinoin	Disrupts	Cell proliferation	65
Resveratrol	Disrupts	Cell proliferation	56
Dexamethasone	Disrupts	Cell proliferation	52
Tretinoin	Affects	Cell proliferation	50
Caffeine	Disrupts	Wound healing	45
Epigallocatechin gallate	Disrupts	Cell proliferation	43
Polyamines	Affects	Cell proliferation	40
Thalidomide	Inhibits	Angiogenesis	37