Table 5: Pharmacological substances affecting the main biological pathways found dysregulated in diabetic retinopathy models by transcriptional profiling in disease.

Substance Semantic relationProcessFrequency

CurcuminDisruptsCell proliferation69
EndostatinsInhibitsAngiogenesis69
TretinoinDisruptsCell proliferation65
ResveratrolDisruptsCell proliferation56
DexamethasoneDisruptsCell proliferation52
TretinoinAffectsCell proliferation50
CaffeineDisruptsWound healing45
Epigallocatechin gallateDisruptsCell proliferation43
PolyaminesAffectsCell proliferation40
ThalidomideInhibitsAngiogenesis37