Review Article
New Hypothesis on Pathogenesis of Ovarian Cancer Lead to Future Tailored Approaches
Table 1
The correlation of the five types of Prat theory and clinical implications.
| | HGSH | LGSH | MC | EC | CCC |
| Prat theory | | | | | | Precursor lesions | STIC | Serous borderline tumor | Cystoadenoma/borderline tumor | Atypical endometriosis | Atypical endometriosis | Pattern of spread | Very early transcoelomic spread | Transcoelomic spread | Usually limited to ovary | Usually limited to pelvis | Usually limited to pelvis | Molecular abnormalities | BRCA P53 | BRAF KRAS | KRAS HER2 | PTEN ARID1A | HNF1 ARID1A | Chemosensitivity | High | Intermediate | Low | High | Low | Prognosis | Poor | Intermediate | Favorable | Favorable | Intermediate |
| Clinical implications | | | | | | Potential target therapies | PARP inhibitors | BRAF KRAS inhibitors | Monoclonal antibodies Anti-HER2 KRAS inhibitors | Not Available | Not available | Potential role of screening | Research of novel early biomarkers | Research of novel early biomarkers | Transvaginal ultrasound + CA125 | Transvaginal ultrasound + CA125 | Transvaginal ultrasound + CA125 |
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HGSC: high-grade serous carcinoma; LGSC: low-grade serous carcinoma; EC: endometrioid carcinoma; CCC: clear cell carcinoma; MC: mucinous carcinoma; STIC: serous tubal intraepithelial carcinoma.
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