STAT6 siRNA Matrix-Loaded Gelatin Nanocarriers: Formulation, Characterization, and Ex Vivo Proof of Concept Using Adenocarcinoma Cells
Figure 6
In vitro STAT6 siRNA release profile for the S6S-GNC formulation compared to the STAT6 siRNA solution. Lyophilized formulation was resuspended in PBS pH 7.4 and filled inside dialysis membrane bags with MWCO of 300 kDa (Sigma, USA). The membrane bags were placed in 50 mL of PBS medium maintained at a temperature of °C with continuous gentle stirring at 300 rpm on a magnetic heating and stirring plate. At specific time intervals, 0.5 mL aliquots of dissolution medium were withdrawn and analyzed using a Biospek UV spectrophotometer. Results are represented as mean ± standard deviations (where ).
