Amelioration of Prallethrin-Induced Oxidative Stress and Hepatotoxicity in Rat by the Administration of Origanum majorana Essential Oil

Figure 5

Paraffin sections of liver stained by haematoxylin and eosin (H&E) for histopathological changes. Control group (a) showing the normal histological structure of the central vein (CV) and surrounding hepatocytes (H) (x64). Prallethrin group showing (b1) severe dilatation and congestion of the portal vein (PV) with oedema (O) in portal area (x40), (b2) massive number of inflammatory cells infiltration (M) in the portal area (x80), and (b3) focal necrosis (N) in the hepatic parenchyma (x40). O. majorana (EO) group (c) showing intact normal histopathological structure of the central vein (CV) and surrounding hepatocytes (x40). Prallethrin-O. majorana (EO) group showing (d1) dilation and congestion in the portal vein (PV), oedema (O), and few inflammatory cells infiltration (M) with dilated bile duct (bd) in portal area (x40) and (d2) diffuse kupffer cells proliferation (K) in between the hepatocytes (x80).