MUC1-Specific Cytotoxic T Lymphocytes in Cancer Therapy: Induction and Challenge

Table 1

Strategies for the induction of anti-MUC1 T cell responses that are being studied in vitro and in vivo.

Author	Strategy	Cancer Model	Effect
Deguchi et al. [43]	𝛼-gal epitope to increase immunogenicity of MUC1	Pancreatic cancer mouse model	Antibody induction, mouse tumor regression, induction of T cell responses
Kovjazin et al. [44]	ImMucin peptide 21mer	Mouse/PBMC of patients	CD4+ and CD8+ T lymphocyte responses in vitro and in vivo
Choi et al. [45]	DNA vaccine (MUC1/HSP70)	B16 mice	cytotoxic T cell response induction/ tumor growth inhibition
Chen et al. [46]	MUC1 mRNA, dendritic cell transfection	Pancreatic cancer	MUC1 mRNA-transfected dendritic cells can induce MUC1-specific CD8+ T cell responses
Wright et al. [47]	MUC1 peptide with substitution of O-glycosylation site	Human adenocarcinoma	O-glycosylation site substitution improves immunogenicity
Kobukai et al. [48]	MPA11P vehicle of a 30mer MUC1 peptide	Mouse	Reduction of tumor size, lymphocyte infiltration
Lakshmiarayanan et al. [49]	Tripartite MUC1 vaccine (TLR2, Thelpher, MUC1 glycopeptides)	Mouse model of mammary cancer	IgG antibodies, cytotoxic T lymphocytes, activation of innate immune response
Sugiura et al. [50]	MUC1 DNA vaccine	Mouse/colon	Induction of CD4+ T cell responses, not CD8+
Ryan et al. [39, 40]	TN MUC1 glycopeptide	Mouse	T cell responses against glycosylated peptides, but not unglycosylated peptides
Choi et al. [51]	MUC1 DNA vaccination, enhanced by mANT2 shRNA	Mouse melanoma	Combination enhanced effects of DNA vaccination, MUC1 CD8+ T cell responses
Jeon et al. [52]	DNA vaccination	Mouse	Tumor growth inhibition, CD8+ IFN-𝛾 increased