Gene Expression Profiling of Human Oocytes Developed and Matured In Vivo or In Vitro

Table 5

Genes which were significantly up-regulated in human oocytes at different stages of maturity.

Up-regulated genes at different stages of oocyte maturity
GV; (immature)	MI; (immature)	MII; (mature)	References
RBBP8, ATR	BRAP, BUB1B, BUB3	RBBP7, RBL2	Gasca et al., 2007 [2]
GBX1, HOXA7		HOXA1, HEX	Huntriss et al., 2006 [19]
Molecular functions of differently expressed genes
(GV versus MII oocytes)
GV; Up-regulated genes; (number)		GV; Down-regulated genes; (number)	References
(i) Nucleic acid binding (149)		(i) Nucleic acid binding (235)
(ii) Zinc finger transcription factor (58)		(ii) Ribosomal protein (101)
(iii) KRAB box transcription factor (41)		(iii) Receptor (39)
(iv) Ligase (31)		(iv) Translation factor (22)
(v) Chaperone (25)		(v) Ribonucleoprotein (15)	Wells and Patrizio, 2008 [26]
(vi) Synthase and synthetase (25)		(vi) Translation elongation factor (14)
(vii) Receptor (22)		(vii) Signaling molecule (13)
(viii) Other RNA-binding factors (19)		(viii) G-protein coupled receptor
(ix) mRNA processing factor (17)		(ix) Tubulin