Table 7: Transcription factors associated with developmental competence of oocytes found by meta-analysis of previously published microarray studies comparing in vivo and in vitro matured oocytes in bovine and monkey, human healthy and polycystic ovaries (PCOS-polycystic ovary syndrome), and mouse young and aged ovaries [38].

Transcripts associated with developmental competence of oocytes
Increased developmental competenceDecreased developmental competence

CPD Carboxypeptidase D precursor PRKG1 cGMP-dependent protein kinase 1, alpha isozyme
SH3BGRLSH3 domain binding glutamic acid-rich-like proteinIGFBP3 Insulin-like growth factor binding protein 3
CDC123 Cell division cycle 123 DUSP1 Dual specificity phosphatase 1
AQP1 Aquaporin 1NDRG4 Ndr4
GNB5Guanine nucleotide binding protein beta 5ATOX1 Copper transport protein
METAP2 Methionine aminopeptidase 2 TMSB10 Thymosin beta-10
UBE2E3Ubiquitin-conjugating enzyme E2E3ATRX Alpha thalassemia/mental retardation syndrome X-linked
USP6NLUSP6 N-terminal-like proteinSHMT2 Serine hydroxymethyltransferase 2
HMGA1 * High Mobility group AT-hook1TGFBR3 * Transforming growth factor beta receptor III
TCTEL1 TCTEL1 protein FANK1 Fibronectin type 3 and ankyrin repeat domains 1 protein
SNRPD3Small nuclear ribonucleoprotein D3 polypeptide PTPN1 Protein tyrosine phosphatase, nonreceptor type 1
MTG1 Mitochondrial GTPase 1 homologDDX55 ATP-dependent RNA helicase DDX55
GKAP1 G kinase anchoring protein 1 SFRP1 * Secreted frizzled-related protein 1
UFM1 Ubiquitin-fold modifier 1 BMP4 Bone morphogenetic protein 4
MITD1Mitochondria interacting transport
domain 1
HIST1HBGHistone H2B type 1-C/E/G
MRPL3Mitochondrial ribosomal protein L3 SEC61G Protein transport protein Sec61 subunit gamma
KIF23 Kinesin family member 23 FOXM1 * Forkhead box protein M1
DDX52DEAD box polypeptide 52NDUFA1 NADH dehydrogenase 1 alpha subcomplex subunit 1
TUSC4 Tumor suppressor candidate 4
JMJD1C Jumonji domain containing 1C
POL2RLDNA-directed RNA polymerases I, II, and III subunit RPABC5
MED1 Mediator complex subunit 1
SLC39A14 Solute carrier family 39 member 14
CALM2 Calmodulin 2
RPS18 40S ribosomal protein S18
INVS Inversion
RBMS1 RNA binding motif single stranded interacting protein 1
PLXNC1 Plexin C1
BTF3l4 Basic transcription factor 3-like 4
MAP3K12 * Mitogen-activated protein 3 kinase 12
PXMP4 Peroxisomal membrane protein 4
EG216818 Ubiquitin
JAM2 Junctional adhesion molecule 2
IFITM1 Interferon-induced transmembrane protein 1
LRRC28Leucine rich repeat containing 28

Transcription regulation
Associated with decreased competence in oocytes

E2f4 65
Sp3 61
Gata-1 62
C/ebp β 62
Rela (P65 NF-Kb Subunit)

Potential biomarkers of oocyte developmental competence.