Serum Brain-Derived Neurotrophic Factor Levels in Different Neurological Diseases

Table 1

Demographic, clinical features, and BDNF serum levels in different study groups.

Diagnosis	CTRL	AD	FTD	LBD	VAD	PD
Sample size	169	266	28	40	91	30
Demographic variables
Gender (% F)	49%	67%	54%	68%	67%	30%
differences versus CTRL 𝑃 =		<0.001	0.688	0.052	0.006	0.073
Age	48.0 ± 15.7	80.1 ± 7.1	71.7 ± 9.9	79.2 ± 5.6	81.9 ± 7.5	67.6 ± 8.4
differences versus CTRL 𝑃 =		<0.001	<0.001	<0.001	<0.001	<0.001
Clinical variables
MMSE score	>27	13.6 ± 8.0	16.1 ± 6.6	15.9 ± 7.4	14.8 ± 8.0	25.4 ± 2.0
HY score						3.58 ± 0.5
Pharmacological treatment
Neuroleptics (−/+)*		118/148	14/14	14/26	44/47	26/44
Benzodiazepines (−/+)		167/99	17/11	28/12	58/33	30/0
Antidepressants (−/+)		142/124	12/16	20/20	27/64	17/13
Mood stabilizers antiepileptics (−/+)		237/29	20/8	37/3	74/17	30/0
Cholinesterase inhibitors (−/+)		193/73	27/1	21/19	87/4	30/0
L-DOPA (−/+)		266/0	28/0	40/0	91/0	0/30
Serum BDNF
ng/mL (mean ± SD)	39.89 ± 9.48	33.16 ± 12.4	31.19 ± 9.68	31.71 ± 11.6	33.06 ± 12.4	46.13 ± 15.3

∗(−/+): not treated/treated.