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BioMed Research International
Volume 2013 (2013), Article ID 902759, 9 pages
http://dx.doi.org/10.1155/2013/902759
Research Article

Effect of Experimental Infection with Haemonchus contortus on Parasitological and Local Cellular Responses in Resistant and Susceptible Young Creole Goats

1INRA, UR143 Unité de Recherches Zootechniques, Domaine Duclos, French West Indies, 97170 Petit-Bourg, France
2UMR703, Ecole Nationale Vétérinaire, Agroalimentaire et de l'Alimentation Nantes-Atlantique, BP 40706, 44307 Nantes, France
3INRA, UE1294 Plateforme Tropicale d’Expérimentation sur l’Animal, Domaine Duclos, French West Indies, 97170 Petit-Bourg, France

Received 11 April 2013; Accepted 9 June 2013

Academic Editor: Pedro Cabrales

Copyright © 2013 J. C. Bambou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study was carried out to evaluate the relationships of cellular changes in the abomasal mucosa and parasitological parameters, by comparing resistant and susceptible young Creole goats (kids) after experimental infection with Haemonchus contortus. The kids were infected over 2 periods (challenges 1 and 2) of 7 and 6 weeks, respectively. Fecal egg count (FEC), blood eosinophilia, packed cell volume (PCV), and body weight were weekly monitored. At the end of both challenges a subgroup of kids was slaughtered for nematode burden measurements and analysis of inflammatory cell infiltration in the abomasal mucosa. The average daily gain was higher in resistant kids after both challenges. Blood eosinophilia and FEC were higher in susceptible kids after both challenges. The number of immature worms and the means of female length were lower after challenge 2 whatever the genetic status. No differences were observed in the eosinophil and mononuclear cell infiltration between challenges 1 and 2 and resistant and susceptible kids. Globule leukocyte infiltration was found higher after the challenge 1 in resistant kids. This effect of the genetic status on globule leukocytes counts but not on the other inflammatory cell highlights the need for further study on the functional activity of these cell populations.