Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients

Table 1

Baseline characteristics of groups NLTX and Placebo.

Characteristics	Total	NLTX	Placebo	P value
		𝑛=27	𝑛=27
Age
Mean ± SD	—	26 ± 11	31 ± 12	0.03^‡
Sex
Male	24 (44.4%)	9 (33.3%)	15 (55.6%)	0.10*
Female	30 (55.6%)	18 (66.7%)	12 (44.4%)
Mode of toxicity
Suicidal	45 (83.3%)	24 (88.9%)	21 (77.8%)	0.48**
Accidental	9 (16.7%)	3 (11.1%)	6 (22.2%)
Formulation
Tablet	20 (37.0%)	10 (37.0%)	10 (37.0%)	>0.99*
Syrup	34 (63.0%)	17 (63.0%)	17 (63.0%)
Ingested MTD doses (mg)
Mean ± SD	130±116	153±142	106±75	0.41^‡
Time since ingestion (hrs)
Mean ± SD	6±6	6±5	6±6	0.34^‡

†Student’s t-test. ^‡Mann-Whitney U test. *Chi-Square test. **Fisher’s exact test.