Effectiveness of Naltrexone in the Prevention of Delayed Respiratory Arrest in Opioid-Naive Methadone-Intoxicated Patients

Table 2

The prehospital status of patients.

Characteristics	Total	NLTX	Placebo	P value
		𝑛=27	𝑛=27
Pre-hospital Apnea
No apnea	43 (79.6%)	23 (85.2%)	20 (74.1%)	0.38^‡
One episode	8 (14.8%)	2 (7.4%)	6 (22.2%)
Two episodes	3 (5.6%)	2 (7.4%)	1 (3.7%)
Bradypnea	27 (50.0%)	11 (40.7%)	16 (59.3%)	0.17*
Naloxone doses (mg)
Mean ± SD	1.5±0.8	1.5±0.7	1.5±1	0.53^‡
Symptoms
Nausea & vomiting	23 (42.6%)	13 (48.1%)	10 (37.0%)	0.41*
Dizziness	14 (25.9%)	7 (25.9%)	7 (25.9%)	>0.99*
Headache	3 (5.6%)	1 (3.7%)	2 (7.4%)	>0.99**
Seizure	3 (5.6%)	2 (7.4%)	1 (3.7%)	>0.99**
Weakness	5 (9.3%)	3 (11.1%)	2 (7.4%)	>0.99**
Fall down	2 (3.7%)	0 (0.0%)	2 (7.4%)	0.49**
Pruritus	2 (3.7%)	0 (0.0%)	2 (7.4%)	0.49**

†Student’s t-test. ^‡Mann-Whitney U test. *Chi-Square test. **Fisher’s exact test.