PPAR𝜹 Agonist GW501516 Inhibits PDGF-Stimulated Pulmonary Arterial Smooth Muscle Cell Function Related to Pathological Vascular Remodeling

Figure 1

Expression patterns of PPAR isoforms in human pulmonary vascular cells. (a) Expression of PPARδ or PPARγ is higher in HPASMCs compared with HPAECs. Results were similar in three independent experiments. (b) PPARα mRNA level in HPASMCs was set to 100.0. Other mRNA levels were expressed relative to this value. Experiments were performed in triplicate and repeated a minimum of three times. ^#𝑃<0.01, ^∗𝑃<0.05 versus PPARα.

(a)

(b)