Preliminary Characterization of Genipin-Cross-Linked Silk Sericin/Poly(vinyl alcohol) Films as Two-Dimensional Wound Dressings for the Healing of Superficial Wounds

Table 4

Level of tissue irritation after subcutaneous implantation with non-cross-linked silk sericin/PVA films and 0.1% w/v genipin-cross-linked silk sericin/PVA films for 3, 7, 14, and 28 days, relative to Sofra tulle as a control.

	Level of irritation
	Non-cross-linked silk sericin/PVA films	0.1% w/v genipin-cross-linked silk sericin/PVA films
3 d	Slightly irritant	Slightly irritant
7 d	Slightly irritant	Slightly irritant
14 d	Slightly irritant	Slightly irritant
28 d	Nonirritant	Slightly irritant