Cytogenetic Abnormality in Exfoliated Cells of Buccal Mucosa in Head and Neck Cancer Patients in the Tunisian Population: Impact of Different Exposure Sources

Table 6

Logistic regression of anomalous cell (mean ± SD/1000 cells) for HNC risk.

Anomalous cell; (mean)	Controls/patients	Crude OR (95% CI)	𝑃	Adjusted OR^b (95% CI)	𝑃	Adjusted OR^c (95% CI)	𝑃
MN^a
Low (≤3.00)	44/12	1.00 (reference)		1.00 (reference)		1.00 (reference)
High (>3.00)	13/33	8.63 (3.24–22.98)	<0.0001	18.13 (5.00–65.62)	<0.0001	69.06 (5.50–185.12)	0.001
BN^a
Low (≤4.10)	45/17	1.00 (reference)		1.00 (reference)		1.00 (reference)
High (>4.10)	12/28	5.62 (2.07–15.24)	0.001	4.91 (1.60–14.66)	0.004	1.87 (0.31–11.11)	NS

OR: odds ratio, CI: confidence interval.
^aThe 75th percentiles of the controls’ MN and BN frequencies were used as the cutoffs to assign the study subjects to either the low-frequency group or the high-frequency group.
^bAdjusted for age and gender.
^cAdjusted for age, gender, tobacco (smoking and chewing), alcohol, and occupational exposure.