Inflammatory Bowel Disease Therapies and Gut Function in a Colitis Mouse Model

Figure 1

Average body weight of male and female C57BL/6 mice. Six-to-eight-week-old IL-10^−/− mice (male and female) were infected with 100 μL 1 × 10⁸ CFU/mL of H. trogontum and then treated with hydrocortisone (HC), exclusive enteral nutrition (EEN), metronidazole (MNZ), or a combination of EEN and MNZ commenced. In the infected control groups, H. trogontum caused a significant weight loss over the period of 4 weeks (versus noninfected controls 𝑃<0.01). However, infected but (EEN, MNZ, and EEN + MNZ) treated mice gained weight over the 4-week treatment period (versus infected controls 𝑃<0.01 for all comparisons). Mice in the HC group rapidly developed weight loss over the 3-week experimental period (versus infected controls 𝑃=NS; versus noninfected controls 𝑃<0.01). NS: not significant; 𝑃>0.05.