Mouse Prostate Epithelial Luminal Cells Lineage Originate in the Basal Layer Where the Primitive Stem/Early Progenitor Cells Reside: Implications for Identifying Prostate Cancer Stem Cells
Figure 4
Keratin 5-expressing cells in the proximal region of prostate tissue after multiple cycles of androgen deprivation and restoration. (a) Schematic representation of the labeling protocol in Keratin 5-tTA-TRE-H2BGFP mice. (b) Mice were sacrificed at the end of the chase and full cycles of label wash-out (involution and regeneration of more than 10 cycles) and tissue sections from the proximal regions of prostate were imaged for endogenous GFP expression indicating the K5 positive cells. Skin tissue was utilized as a positive control.
