Figure 4: Suppressive effects of milk thistle extract (MTE) and silibinin on serum RANKL/OPG ratio in ovariectomized (OVX) mice. OVX mice were orally administrated with 10 mg/kg/day MTE or 10 mg/kg/day silibinin daily for 8 weeks. Serum levels of OPG and RANKL were determined by using ELISA kits. Values in bar graphs (mean ± SEM, ) not sharing a letter indicate significant difference at .