Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013, Article ID 921348, 6 pages
http://dx.doi.org/10.1155/2013/921348
Research Article

Possible Role of Hyperinsulinemia and Insulin Resistance in Lower Vitamin D Levels in Overweight and Obese Patients

1Clinical Nutrition Unit, Department of Biomedical Sciences and Human Oncology, Section of Clinical Oncology, School of Medicine, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
2Department of Biomedical Sciences and Human Oncology, School of Medicine, University of Bari, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy
3Outpatient Clinic for Metabolic Diseases and Endocrinology, Conversano Hospital, ASL Bari, 70014 Conversano, Italy
4Section of Endocrinology and Metabolic Diseases, Department of Emergency and Organ Transplantation, School of Medicine, University of Bari, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy

Received 5 August 2012; Revised 6 December 2012; Accepted 8 December 2012

Academic Editor: Joseph Fomusi Ndisang

Copyright © 2013 Giovanni De Pergola et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [17 citations]

The following is the list of published articles that have cited the current article.

  • M. E. Atabek, Beray Selver Eklioglu, Nesibe Akyurek, and Hayrullah Alp, “Association between vitamin D level and cardiovascular risk in obese children and adolescents,” Journal of Pediatric Endocrinology & Metabolism, vol. 27, no. 7-8, pp. 661–666, 2014. View at Publisher · View at Google Scholar
  • A. Esteghamati, Z. Aryan, A. Esteghamati, and M. Nakhjavani, “Differences in vitamin D concentration between metabolically healthy and unhealthy obese adults: Associations with inflammatory and cardiometabolic markers in 4391 subjects,” Diabetes & Metabolism, 2014. View at Publisher · View at Google Scholar
  • Sanja Soskić, Edita Stokić, and Esma R. Isenović, “The relationship between vitamin D and obesity,” Current Medical Research and Opinion, pp. 1–3, 2014. View at Publisher · View at Google Scholar
  • Patchaya Boonchaya-anant, Michael F. Holick, and Caroline M. Apovian, “Serum 25-Hydroxyvitamin D Levels and Metabolic Health Status in Extremely Obese Individuals,” Obesity, vol. 22, no. 12, pp. 2539–2543, 2014. View at Publisher · View at Google Scholar
  • A. Esteghamati, Z. Aryan, A. R. Esteghamati, and M. Nakhjavani, “Vitamin D Deficiency is Associated with Insulin Resistance in Nondiabetics and Reduced Insulin Production in Type 2 Diabetics,” Hormone And Metabolic Research, vol. 47, no. 4, pp. 273–279, 2015. View at Publisher · View at Google Scholar
  • Edita Stokic, Aleksandar Kupusinac, Dragana Tomic-Naglic, Branka Kovacev Zavisic, Milena Mitrovic, Dragana Smiljenic, Sanja Soskic, and Esma Isenovic, “Obesity and Vitamin D Deficiency: Trends to Promote a More Proatherogenic Cardiometabolic Risk Profile,” Angiology, vol. 66, no. 3, pp. 237–243, 2015. View at Publisher · View at Google Scholar
  • V. A. Giagulli, M. D. Carbone, M. I. Ramunni, B. Licchelli, G. De Pergola, C. Sabbà, E. Guastamacchia, and V. Triggiani, “Adding liraglutide to lifestyle changes, metformin and testosterone therapy boosts erectile function in diabetic obese men with overt hypogonadism,” Andrology, 2015. View at Publisher · View at Google Scholar
  • Giovanni De Pergola, Adele Nardecchia, Michela Cirillo, Barbara Boninfante, Marcello Sciaraffia, Vito Angelo Giagulli, Vincenzo Triggiani, and Franco Silvestris, “Higher Waist Circumference, Fasting Hyperinsulinemia and Insulin Resistance Characterize Hypertensive Patients with Impaired Glucose Metabolism,” Endocrine Metabolic & Immune Disorders-Drug Targets, vol. 15, no. 4, pp. 297–301, 2015. View at Publisher · View at Google Scholar
  • Reem M. Al Haj Ahmad, and Hayder A. Al-Domi, “Complement 3 serum levels as a pro-inflammatory biomarker for insulin resistance in obesity,” Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2016. View at Publisher · View at Google Scholar
  • Loanne Rocha dos Santos, Alana Gleyka Amaral Lima, Amanda Ferraz Braz, Stéfany Rodrigues de Sousa Melo, Jennifer Beatriz Silva Morais, Juliana Soares Severo, Ana Raquel Soares de Oliveira, Kyria Jayanne Clímaco Cruz, and Dilina do Nascimento Marreiro, “Role of vitamin D in insulin resistance in obese individuals,” Nutrire, vol. 42, no. 1, 2017. View at Publisher · View at Google Scholar
  • Silvia Savastano, Luigi Barrea, Maria Cristina Savanelli, Francesca Nappi, Carolina Di Somma, Francesco Orio, and Annamaria Colao, “Low vitamin D status and obesity: Role of nutritionist,” Reviews in Endocrine and Metabolic Disorders, 2017. View at Publisher · View at Google Scholar
  • Krista MacDonald, Kristine Godziuk, Jason Yap, Rena LaFrance, Mohammad Ansarian, Andrea Haqq, and Diana R. Mager, “Vitamin D Status, Cardiometabolic, Liver, and Mental Health Status in Obese Youth Attending a Pediatric Weight Management Center,” Journal of Pediatric Gastroenterology and Nutrition, vol. 65, no. 4, pp. 462–466, 2017. View at Publisher · View at Google Scholar
  • Reem M. Al Haj Ahmad, and Hayder A. Al-Domi, “Vitamin D Insufficiency Predicts Elevated Levels of Complement 3 Independent of Insulin Resistance and BMI,” Journal of Nutritional Science and Vitaminology, vol. 63, no. 3, pp. 155–160, 2017. View at Publisher · View at Google Scholar
  • Hayder A. Al-Domi, and Reem M. Al Haj Ahmad, “Association between complement component C3 and body composition: A possible obesity inflammatory biomarker for insulin resistance,” Asia Pacific Journal of Clinical Nutrition, vol. 26, no. 6, pp. 1082–1087, 2017. View at Publisher · View at Google Scholar
  • Shamaila Rafiq, and Per Jeppesen, “Body Mass Index, Vitamin D, and Type 2 Diabetes: A Systematic Review and Meta-Analysis,” Nutrients, vol. 10, no. 9, pp. 1182, 2018. View at Publisher · View at Google Scholar
  • Catherine McCormack, Shalem Leemaqz, Denise Furness, Gustaaf Dekker, and Claire Roberts, “Association between vitamin D status and hyperinsulinism,” The Journal of Maternal-Fetal & Neonatal Medicine, pp. 1–4, 2018. View at Publisher · View at Google Scholar
  • Shamaila Rafiq, and Per Jeppesen, “Is Hypovitaminosis D Related to Incidence of Type 2 Diabetes and High Fasting Glucose Level in Healthy Subjects: A Systematic Review and Meta-Analysis of Observational Studies,” Nutrients, vol. 10, no. 1, pp. 59, 2018. View at Publisher · View at Google Scholar