Different Effects of the Immunomodulatory Drug GMDP Immobilized onto Aminopropyl Modified and Unmodified Mesoporous Silica Nanoparticles upon Peritoneal Macrophages of Women with Endometriosis

Table 3

Comparative characteristics in vitro of effects of free GMDP and GMDP immobilized on UMNPs and AMNPs on spontaneous expression of functional and SR molecules by peritoneal macrophages of women with endometriosis.

Parameter, %	Macrophages + RPMI 1640 medium (control); (𝑛=31)	Macrophages + free GMDP; (𝑛=16)	Macrophages + GMDP immobilized on AMNPs; (𝑛=7)	Macrophages + GMDP immobilized on UMNPs; (𝑛=6)
CD36 + (SR-B)	63.73±2.75	75.67±3.15^∗∗	84.10±1.55^∗∗∗x	65.78±4.23^yy
CD204 + (SR-AI)	55.11±2.18	69.79±3.75^∗∗∗	69.48±3.64^∗∗	59.73±4.47

∗Statistically significant differences between data received for stimulated macrophages and control values (**𝑃<0.01, ***𝑃<0.01).
^xStatistically significant differences between data received for free GMDP and GMDP, immobilized on AMNPs (^x𝑃<0.05).
^yStatistically significant differences between data received for GMDP, immobilized on AMNPs and UMNPs (^yy𝑃<0.01).