Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives

Table 3

Antimycobacterial activity of compounds 5a–g against M. tuberculosis H₃₇Rv and INH-resistant Mycobacterium tuberculosis.

Compound	MIC^a; (µM)	MIC^b; (µM)	6.12 cytotoxicity; (µg/mL)
5a	6.219	64.78	>62.5
5b	0.195	24.12	>62.5
5c	4.320	26.12	>62.5
5d	0.135	16.25	>62.5
5e	6.195	2.10	>62.5
5f	6.219	41.72	>62.5
5g	0.112	6.12	>62.5
Isoniazid	0.73	11.37	>62.5

aMycobacterium tuberculosis H₃₇Rv and ^bINH-resistant Mycobacterium tuberculosis.