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BioMed Research International
Volume 2013 (2013), Article ID 926584, 8 pages
http://dx.doi.org/10.1155/2013/926584
Research Article

Deposition of Doxorubicin in Rats following Administration of Three Newly Synthesized Doxorubicin Conjugates

1Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi’an, Shaan’xi 710032, China
2Department of Obstetrics & Gynecology, PLA General Hospital, Beijing 100853, China
3Department of Clinic Pharmacology, Wuhan General Hospital of Guangzhou Military Area Command, Wuhan, Hubei 430070, China
4Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaan’xi 710038, China
5Department of Radiation Medicine, School of Public Health, Fourth Military Medical University, Xi’an, Shaan’xi 710032, China
6Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaan’xi 710032, China

Received 1 October 2013; Accepted 3 November 2013

Academic Editor: Peng Zhang

Copyright © 2013 Menglei Huan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The mass spectrum and MRM chromatograms of doxorubicin were illustrated in the supplementary material. The mass spectrum of doxorubicin was showed in Figure s1, the monitored range for signal acquisition of the fragmented DOX ions was from 542 to 395 m/z. MRM chromatograms of doxorubicin and I.S. (resveratrol) in rat plasma and tissue samples were showed in Figure s2. The retention times for doxorubicin and resveratrol were 2.77 min and 2.40 min, respectively. In addition, the method of LC-MS/MS were also evaluated by precision, accuracy, and extraction recoveries of doxorubicin.

  1. Supplementary Material