High-Dose, but Not Low-Dose, Aspirin Impairs Anticontractile Effect of Ticagrelor following ADP Stimulation in Rat Tail Artery Smooth Muscle Cells
Figure 4
Concentration-response curves in arteries without vascular endothelium obtained for phenylephrine in the absence and presence of low-dose aspirin, high-dose aspirin, and ticagrelor coadministered with 2-MeS-ADP. Points and whiskers display mean values ± standard deviations. A curve for PHE represents a control curve for TIC, ASA (L), and ASA (H) while curves for ASA (L) and ASA (H) constitute control curves for ASA (L) + TIC and ASA (H) + TIC, respectively. ASA (H): high-dose aspirin; ASA (L): low-dose aspirin; Ea/Em: % of maximal response; PHE: phenylephrine; TIC: ticagrelor; 2-MeS-ADP: stable analogue of adenosine diphosphate; *a value of when comparing the control curve for points of effect between 20% and 80% of the maximal response.
