A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer

Table 2

BRCA1 and BRCA2 gene mutations in Northern Europe.

Country	BRCA1  mutations	BRCA2 mutations	Founder mutations
Finland	c.5095C>T [3],4216-2nt A–>G; 5370C>T [159]	4088insA,; c.68-80insT,; c.793+34T>G; 999del5; 6503delTT [159]	4216-2ntA>G; 5370C>T; 999del5; 6503delTT [159]
Sweden	3172ins5, 2594delC; 1806C>T, 1201del11; [47, 48]	4486delG; [47, 48]	3172ins5, 2594delC; 1806C>T, 1201del11; 4486delG [47, 48]
Denmark	3172ins5 and 1201del11; 1675delA and 1135insC; [38, 49]	2594delC, 5382insC; 3829delT and Q563X; 3438G>T, 1675delA,; 999del5; [38, 49]	Iceland/Denmark (999del5); Norway/Denmark (1675delA and 1135insC); Swedish/Danish founder (3172ins5 and 1201del11, 3438G>T, 1675delA); Danish specific: 2594delC, 5382insC, 3829delT, and Q563X; [38, 49]
Norway	1135insA, 1675delA, 816delGT, 3203del11, and 3347delAG [50, 51]	—	—
Iceland	G5193A [54]	999del5 [54]	999del5, G5193A [54]
Netherland	Exon 13 and 22 del; 2804delAA; IVS2011G>A, IVS21-36del510; 5382insC, 1411insT, 2138delA 2312del5, 2457C4T, 185insA, 185delAG [59]	6503delTT, 8295T4A,; 9900insA, 5579insA, 7647delTG [59]	5579insA, exon 13 del; [59], 2804delA [160]