Review Article
A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer
Table 5
BRCA1 and BRCA2 gene mutations in America.
| | Country | BRCA1 mutations | BRCA2 mutations | Founder mutations |
| | Cuba | c.5231delT [188] | c.3394C>T, c.7697T>C [188] | — | | Costa Rica | C3522T [189] | 5531delTT, C5507G and 6174delT [189] | — | | Chile | 185AGdel [39, 104] | c.5373_5376 del GTAT, c.373G>T [104] | — | | Brazil | 5382insC [101, 102, 190] | S2219X, C1290Y [101], 6633del5 [102] | — | | Colombia (Hispanic and Colombia) | 3450delCAAG [33, 191] and A1708E (polymorphism) [33]
Exons 9–12 del [97] | 3034delACAA [33] | 3450delCAAG [191]
Exons 9–12 del (Mexican founder) [97] | Bahamas
| IVS13+1G>A, 4730insG, T5443G, IVS16+6T>C, 943ins10, 185delAG [103] | 818delA, exons 8-9 del [105]
| 818delA [105] | Venezuela
| c.951_952insA, c.1129_1135insA, c.4603G>T and IVS20+1G>A [192] | c.3036_3039delACAA, c.6024_6025_delTA, c.2732_2733insA and c.3870_3873delG [192] | — | | Puerto Rico | Exons 1-2 del [193] | 4150G>T, 6027del4 [193] | — | | Mexico | c.3124_3133delAGCAATATTA
c.2805_2808delAGAT [194] | c.5114_5117delTAAA
c.2639_2640delTG [194] | — |
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