Table 6: BRCA1 and BRCA2 gene mutations in Northern and Eastern Asia.

CountryBRCA1 mutationsBRCA2 mutationsFounder mutations

Turkey5382insC, 5622C>T [22, 195, 196]6880 insG and 3034 del AAAC [197]Maybe 5382insC [195]
Russia5382insC [130, 131], 4153delA [129]
185delAG [128]
695insT, 1528del4, 9318del4, S1099X [131]5382insC [131]
Japanc.307T>A [115]
5802delAATT, 8732C>A, c.2835C>A
[114, 115]
c.188T>A, c.2800C>T [110]
c.2835C>A, c.307T>A, 5802delAATT
[114, 115]
Korea509C>A, c.2333delC, c.4065_4068delTCAA 3746_3747insA (c.3627_3628insA ), 5199G>T (c.5080G>T) [110, 198]
c.7480C>T, 1627A.T
3972delTGAG, 7708C.T
[110, 111, 198, 199]
c.7480C>T
[110, 111, 199]
China3478del5, 5589del8, 1100delAT, 2778G>A, 3552C>T [117, 118], exon 10 dup, 5,273G>A [108, 117]
c.470_471delCT, c.3342_3345delAGAA, c.5406+1_5406+3delGTA and c.981_982delAT [120]
7883delTTAA [200]
c.2808_2811delACAA, c.3109C>T, c.7436_7805del370, and c.9097_9098insA [120]
Hong Kong: 5589del8, 1100delAT
[121]
Southern China: c.3109C>T, c.3109C>T, c.7436_7805del370, c.981_982delAT, c.7436_7805del370, and c.9097_9098insA [120]
2845A>T [201], 3300delA, T320G [202]
c.5191C>A [203]
2670delC, 3073delT, and 6696-7delTC [204] 3300delA, T320G