Review Article

Insight into Biological Apatite: Physiochemical Properties and Preparation Approaches

Table 4

Comparison between preparation approaches for biological apatite.

MethodsAdvantagesDisadvantages

Thermal treatment [5, 11, 14, 16, 17, 37, 57, 61]Relatively low requirement for equipment
Simple procedure
Manageable conditions
Low risk in disease infection
Relatively low cost
Large amount of resultant
Unpredictable effect of heating on apatite crystals
Properties of resultant vary upon different sintering conditions

Chemical treatment [64, 65]Possible reservation of the original crystal form and composition
Avoidance of heating effect
Supplementary role for other methods
Residual chemical and organic components
Possible precipitation of amorphous Ca-P phases [34]
Time consuming

Low power plasma ashing [13, 15, 63]Possible reservation of the original crystal form and composition
Avoidance of heating effect, partial dissolution, and recrystallization
Relatively complex procedure
Time consuming
Small amount of resultant
Special equipment are required

Supercritical CO2 fluid extraction [66]Relatively low cost
Possible reservation of the original crystal form and composition
Avoidance of heating effect, partial dissolution, and recrystallization
Large amount of resultant
Time consuming
Residual organic components
Special equipment are required

Hydrothermal hydrolysis [5]No residual organic components
Simple procedure
Manageable conditions
Special equipment are required
Unpredictable effect of high pressure on apatite crystals
Properties of resultant vary upon different hydrolysis conditions