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Methods | Advantages | Disadvantages |
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Thermal treatment [5, 11, 14, 16, 17, 37, 57, 61] | Relatively low requirement for equipment Simple procedure Manageable conditions Low risk in disease infection Relatively low cost Large amount of resultant | Unpredictable effect of heating on apatite crystals Properties of resultant vary upon different sintering conditions |
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Chemical treatment [64, 65] | Possible reservation of the original crystal form and composition Avoidance of heating effect Supplementary role for other methods | Residual chemical and organic components Possible precipitation of amorphous Ca-P phases [34] Time consuming |
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Low power plasma ashing [13, 15, 63] | Possible reservation of the original crystal form and composition Avoidance of heating effect, partial dissolution, and recrystallization | Relatively complex procedure Time consuming Small amount of resultant Special equipment are required |
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Supercritical CO2 fluid extraction [66] | Relatively low cost Possible reservation of the original crystal form and composition Avoidance of heating effect, partial dissolution, and recrystallization Large amount of resultant | Time consuming Residual organic components Special equipment are required |
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Hydrothermal hydrolysis [5] | No residual organic components Simple procedure Manageable conditions | Special equipment are required Unpredictable effect of high pressure on apatite crystals Properties of resultant vary upon different hydrolysis conditions |
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