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This article has been retracted as it is found to contain a significant amount of materials without referencing, from the paper “Preventative and Therapeutic Role of Probiotics in Various Allergic and Autoimmune Disorders An Up-to-Date Literature Review of Essential Experimental and Clinical Data,” Öner Özdemir, Journal of Evidence-Based Complementary & Alternative Medicine. vol. 18, no. 2, pp. 121-151, April 2013.

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  1. Ö. Özdemir and A. Yasemin Göksu Erol, “Preventative and therapeutic probiotic use in allergic skin conditions: experimental and clinical findings,” BioMed Research International, vol. 2013, Article ID 932391, 17 pages, 2013.
BioMed Research International
Volume 2013, Article ID 932391, 17 pages
Review Article

Preventative and Therapeutic Probiotic Use in Allergic Skin Conditions: Experimental and Clinical Findings

1Department of Pediatrics, Division of Allergy and Immunology, Research and Training Hospital of Sakarya University, Faculty of Medicine, Sakarya University, Adnan Menderes Caddesi, Sağlık Sokak No. 195, Adapazarı, 54100 Sakarya, Turkey
2Department of Histology and Embryology, Faculty of Medicine, Afyon Kocatepe University, 03200 Afyonkarahisar, Turkey

Received 21 April 2013; Accepted 18 July 2013

Academic Editor: Ibrahim Banat

Copyright © 2013 Öner Özdemir and Azize Yasemin Göksu Erol. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Probiotics are ingested live microbes that can modify intestinal microbial populations in a way that benefits the host. The interest in probiotic preventative/therapeutic potential in allergic diseases stemmed from the fact that probiotics have been shown to improve intestinal dysbiosis and permeability and to reduce inflammatory cytokines in human and murine experimental models. Enhanced presence of probiotic bacteria in the intestinal microbiota is found to correlate with protection against allergy. Therefore, many studies have been recently designed to examine the efficacy of probiotics, but the literature on the allergic skin disorders is still very scarce. Here, our objective is to summarize and evaluate the available knowledge from randomized or nonrandomized controlled trials of probiotic use in allergic skin conditions. Clinical improvement especially in IgE-sensitized eczema and experimental models such as atopic dermatitis-like lesions (trinitrochlorobenzene and picryl chloride sensitizations) and allergic contact dermatitis (dinitrofluorobenzene sensitization) has been reported. Although there is a very promising evidence to recommend the addition of probiotics into foods, probiotics do not have a proven role in the prevention or the therapy of allergic skin disorders. Thus, being aware of possible measures, such as probiotics use, to prevent/heal atopic diseases is essential for the practicing allergy specialist.