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BioMed Research International
Volume 2013, Article ID 932691, 6 pages
Review Article

Potential of RAS Inhibition to Improve Metabolic Bone Disorders

1Center for Systems Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, China
2School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
3Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong

Received 24 May 2013; Accepted 2 July 2013

Academic Editor: John J. Gildea

Copyright © 2013 Yoseph Gebru et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metabolic bone disorder is usually caused by abnormalities of minerals and hormones metabolism. Recently, it has been proved by several studies that the renin-angiotensin system (RAS) in local bone tissue is directly involved in bone metabolism. Activation of skeletal RAS plays an important role in bone metabolic disorders. Based on in vitro, in vivo, and clinical studies, this review explains the roles of RAS in bone metabolism and also covers the potential approaches and beneficial effects of RAS inhibition on bone health. Differential strategies for inhibiting RAS can be employed to maintain bone health, which are attributed primarily to the reduced level of angiotensin II (AngII) and suppressed stimulation of the AngII signaling pathway. The use of renin inhibitors, angiotensin-converting enzyme inhibitors, and AngII receptor blockers either individually or in combination with each other could have promising results in fighting bone metabolic disorders associated with other cardiovascular diseases as well as independent bone injuries.