- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
BioMed Research International
Volume 2013 (2013), Article ID 941764, 13 pages
Neurotensin Modulates the Migratory and Inflammatory Response of Macrophages under Hyperglycemic Conditions
1Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
2CIEPQPF, Chemical Engineering Department, FCTUC, University of Coimbra, 3030-790 Coimbra, Portugal
3Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal
4The Portuguese Diabetes Association (APDP), Rua Do Salitre, No. 118-120, 1250-203 Lisboa, Portugal
Received 8 April 2013; Revised 24 June 2013; Accepted 28 June 2013
Academic Editor: Senthil K. Venugopal
Copyright © 2013 Liane I. F. Moura et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. E. Shaw, R. A. Sicree, and P. Z. Zimmet, “Global estimates of the prevalence of diabetes for 2010 and 2030,” Diabetes Research and Clinical Practice, vol. 87, no. 1, pp. 4–14, 2010.
- H. Brem and M. Tomic-Canic, “Cellular and molecular basis of wound healing in diabetes,” Journal of Clinical Investigation, vol. 117, no. 5, pp. 1219–1222, 2007.
- C.-C. E. Lan, I.-H. Liu, A.-H. Fang, C.-H. Wen, and C.-S. Wu, “Hyperglycaemic conditions decrease cultured keratinocyte mobility: implications for impaired wound healing in patients with diabetes,” British Journal of Dermatology, vol. 159, no. 5, pp. 1103–1115, 2008.
- A. Tellechea, E. Leal, A. Veves, and E. Carvalho, “Inflammatory and angiogenic abnormalities in diabetic wound healing: role of neuropeptides and therapeutic perspectives,” The Open Circulation and Vascular Journal, vol. 3, pp. 43–55, 2010.
- L. Pradhan, C. Nabzdyk, N. D. Andersen, F. W. LoGerfo, and A. Veves, “Inflammation and neuropeptides: the connection in diabetic wound healing,” Expert Reviews in Molecular Medicine, vol. 11, article e2, 2009.
- H. Kämpfer, R. Schmidt, G. Geisslinger, J. Pfeilschifter, and S. Frank, “Wound inflammation in diabetic ob/ob mice: functional coupling of prostaglandin biosynthesis to cyclooxygenase-1 activity in diabetes-impaired wound healing,” Diabetes, vol. 54, no. 5, pp. 1543–1551, 2005.
- T. J. Koh and L. A. DiPietro, “Inflammation and wound healing: the role of the macrophage,” Expert Reviews in Molecular Medicine, vol. 13, article e23, 2011.
- J. D. Bagdade, R. K. Root, and R. J. Bulger, “Impaired leukocyte function in patients with poorly controlled diabetes,” Diabetes, vol. 23, no. 1, pp. 9–15, 1974.
- T. C. Alba-Loureiro, C. D. Munhoz, J. O. Martins et al., “Neutrophil function and metabolism in individuals with diabetes mellitus,” Brazilian Journal of Medical and Biological Research, vol. 40, no. 8, pp. 1037–1044, 2007.
- S. Khanna, S. Biswas, Y. Shang et al., “Macrophage dysfunction impairs resolution of inflammation in the wounds of diabetic mice,” PLoS ONE, vol. 5, no. 3, Article ID e9539, 2010.
- F. O. Martinez, A. Sica, A. Mantovani, and M. Locati, “Macrophage activation and polarization,” Frontiers in Bioscience, vol. 13, no. 2, pp. 453–461, 2008.
- L. F. de Souza, F. R. Jardim, I. P. Sauter, M. M. de Souza, and E. A. Bernard, “High glucose increases RAW 264.7 macrophages activation by lipoteichoic acid from Staphylococcus aureus,” Clinica Chimica Acta, vol. 398, no. 1-2, pp. 130–133, 2008.
- I. J. Elenkov, “Neurohormonal-cytokine interactions: implications for inflammation, common human diseases and well-being,” Neurochemistry International, vol. 52, no. 1, pp. 40–51, 2008.
- P. Brun, C. Mastrotto, E. Beggiao et al., “Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation,” American Journal of Physiology, vol. 288, no. 4, pp. G621–G629, 2005.
- A. V. Delgado, A. T. McManus, and J. P. Chambers, “Exogenous administration of substance P enhances wound healing in a novel skin-injury model,” Experimental Biology and Medicine, vol. 230, no. 4, pp. 271–280, 2005.
- M. Toda, T. Suzuki, K. Hosono et al., “Roles of calcitonin gene-related peptide in facilitation of wound healing and angiogenesis,” Biomedicine and Pharmacotherapy, vol. 62, no. 6, pp. 352–359, 2008.
- L. Pradhan, X. Cai, S. Wu et al., “Gene expression of pro-inflammatory cytokines and neuropeptides in diabetic wound healing,” Journal of Surgical Research, vol. 167, no. 2, pp. 336–342, 2011.
- M. H. Jiang, E. Chung, G. F. Chi, W. Ahn, J. E. Lim, H. S. Hong, et al., “Substance P induces M2-type macrophages after spinal cord injury,” Neuroreport, vol. 23, pp. 786–792, 2012.
- L. H. Lazarus, M. R. Brown, and M. H. Perrin, “Distribution, localization and characteristics of neurotensin binding sites in the rat brain,” Neuropharmacology, vol. 16, no. 9, pp. 625–629, 1977.
- D. Zhao, Y. Zhan, H. Zeng, H.-W. Koon, M. P. Moyer, and C. Pothoulakis, “Neurotensin stimulates interleukin-8 expression through modulation of IκBα phosphorylation and p65 transcriptional activity: involvement of protein kinase Cα,” Molecular Pharmacology, vol. 67, no. 6, pp. 2025–2031, 2005.
- H. S. Kim, S. Yumkham, J. H. Choi et al., “Neurotensin enhances nitric oxide generation via the JAK2-STAT1 pathway in murine macrophage RAW 264.7 cells during costimulation with LPS and IFNγ,” Neuropeptides, vol. 40, no. 3, pp. 221–229, 2006.
- L. da Silva, B. M. Neves, L. Moura, M. T. Cruz, and E. Carvalho, “Neurotensin downregulates the pro-inflammatory properties of skin dendritic cells and increases epidermal growth factor expression,” Biochimica et Biophysica Acta, vol. 1813, no. 10, pp. 1863–1871, 2011.
- H.-P. Hartung, “Activation of macrophages by neuropeptides,” Brain Behavior and Immunity, vol. 2, no. 4, pp. 275–281, 1988.
- D. Ganea and M. Delgado, “Neuropeptides as modulators of macrophage functions. Regulation of cytokine production and antigen presentation by VIP and PACAP,” Archivum Immunologiae et Therapiae Experimentalis, vol. 49, no. 2, pp. 101–110, 2001.
- J.-P. Vincent, J. Mazella, and P. Kitabgi, “Neurotensin and neurotensin receptors,” Trends in Pharmacological Sciences, vol. 20, no. 7, pp. 302–309, 1999.
- M. W. Pfaffl, “A new mathematical model for relative quantification in real-time RT-PCR,” Nucleic Acids Research, vol. 29, no. 9, article e45, 2001.
- H. K. Jeon, N. P. Jung, I. H. Choi, Y. K. Oh, H. C. Shin, and B. J. Gwag, “Substance P augments nitric oxide production and gene expression in murine macrophages,” Immunopharmacology, vol. 41, no. 3, pp. 219–226, 1999.
- R. Yaraee, M. Ebtekar, A. Ahmadiani, and F. Sabahi, “Neuropeptides (SP and CGRP) augment pro-inflammatory cytokine production in HSV-infected macrophages,” International Immunopharmacology, vol. 3, no. 13-14, pp. 1883–1887, 2003.
- S. Martin, J.-P. Vincent, and J. Mazella, “Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia,” Journal of Neuroscience, vol. 23, no. 4, pp. 1198–1205, 2003.
- M. De La Fuente, J. J. Garrido, R. M. Arahuetes, and A. Hernanz, “Stimulation of phagocytic function in mouse macrophages by neurotensin and neuromedin N,” Journal of Neuroimmunology, vol. 42, no. 1, pp. 97–104, 1993.
- S. Devaraj, S. K. Venugopal, U. Singh, and I. Jialal, “Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase C-α and -β,” Diabetes, vol. 54, no. 1, pp. 85–91, 2005.
- E. Hatanaka, P. T. Monteagudo, M. S. M. Marrocos, and A. Campa, “Neutrophils and monocytes as potentially important sources of proinflammatory cytokines in diabetes,” Clinical and Experimental Immunology, vol. 146, no. 3, pp. 443–447, 2006.
- M. R. Dasu, S. Devaraj, L. Zhao, D. H. Hwang, and I. Jialal, “High glucose induces toll-like receptor expression in human monocytes Mechanism of activation,” Diabetes, vol. 57, no. 11, pp. 3090–3098, 2008.
- J. M. Cavaillon, “Cytokines and macrophages,” Biomedicine and Pharmacotherapy, vol. 48, no. 10, pp. 445–453, 1994.
- N. Silswal, A. K. Singh, B. Aruna, S. Mukhopadhyay, S. Ghosh, and N. Z. Ehtesham, “Human resistin stimulates the pro-inflammatory cytokines TNF-α and IL-12 in macrophages by NF-κB-dependent pathway,” Biochemical and Biophysical Research Communications, vol. 334, no. 4, pp. 1092–1101, 2005.
- J. R. Hill, G. Kwon, C. A. Marshall, and M. L. McDaniel, “Hyperglycemic levels of glucose inhibit interleukin 1 release from RAW 264.7 murine macrophages by activation of protein kinase C,” Journal of Biological Chemistry, vol. 273, no. 6, pp. 3308–3313, 1998.
- C. Sia, “Imbalance in Th cell polarization and its relevance in type 1 diabetes mellitus,” Review of Diabetic Studies, vol. 2, pp. 182–186, 2005.
- E. Dicou, J.-P. Vincent, and J. Mazella, “Neurotensin receptor-3/sortilin mediates neurotensin-induced cytokine/chemokine expression in a marine microglial cell line,” Journal of Neuroscience Research, vol. 78, no. 1, pp. 92–99, 2004.
- M. C. Dvoráková, U. Pfeil, J. Kuncová et al., “Down-regulation of vasoactive intestinal peptide and altered expression of its receptors in rat diabetic cardiomyopathy,” Cell and Tissue Research, vol. 323, no. 3, pp. 383–393, 2006.
- E. Hermans and J.-M. Maloteaux, “Mechanisms of regulation of neurotensin receptors,” Pharmacology and Therapeutics, vol. 79, no. 2, pp. 89–104, 1998.
- J. Mazella, “Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?” Cellular Signalling, vol. 13, no. 1, pp. 1–6, 2001.
- F. Mule, R. Serio, and A. Postorino, “Motility pattern of isolated rat proximal colon and excitatory action of neurotensin,” European Journal of Pharmacology, vol. 275, no. 2, pp. 131–137, 1995.
- S. Hashim, Y. Li, and M. B. Anand-Srivastava, “G protein-linked cell signaling and cardiovascular functions in diabetes/hyperglycemia,” Cell Biochemistry and Biophysics, vol. 44, no. 1, pp. 51–64, 2006.
- A. Akabayashi, C. T. B. V. Zaia, I. Silva, H. J. Chae, and S. F. Leibowitz, “Neuropeptide Y in the arcuate nucleus is modulated by alterations in glucose utilization,” Brain Research, vol. 621, no. 2, pp. 343–348, 1993.
- R. Matyal, F. Mahmood, M. Robich et al., “Chronic type II diabetes mellitus leads to changes in neuropeptide y receptor expression and distribution in human myocardial tissue,” European Journal of Pharmacology, vol. 665, no. 1–3, pp. 19–28, 2011.