Urinary IgG and α2-Macroglobulin Are Powerful Predictors of Outcome and Responsiveness to Steroids and Cyclophosphamide in Idiopathic Focal Segmental Glomerulosclerosis with Nephrotic Syndrome

Table 2

Area under the ROC curve (AUC), cutoffs, sensitivity, and specificity for progression to ESRD of clinical, proteinuric, and histological parameters.

Risk factors	AUC	𝑃	Cutoff	Sensitivity %	Specificity %
eGFR	0.489	(0.784)	≥68	67	52
FE IgG	0.973	(<0.0001)	≥0.112	100	90
UP/C	0.904	(<0.0001)	≥5980	100	76
FE α1m	0.897	(<0.0001)	≥0.362	78	93
α2m/C	0.891	(<0.0001)	≥4.79	89	86
24 hP	0.872	(0.001)	≥6.8	100	69
GGS	0.470	(0.798)	≥7.5%	38%	59%
TID score	0.477	(0.844)	≥3.5	25%	93%
SS	0.701	(0.087)	>16%	88%	59%

eGFR: estimated GFR; FE IgG: fractional excretion of IgG; UP/C: urinary protein/creatinine ratio; FE α1m: fractional excretion of α1-microglobulin; α2m/C: urinary α2-macroglobulin/creatinine ratio; 24 hP: 24 hour proteinuria; GGS: global glomerular sclerosis; TID score: tubulointerstitial damage score; SS: segmental sclerosis.