Urinary IgG and α2-Macroglobulin Are Powerful Predictors of Outcome and Responsiveness to Steroids and Cyclophosphamide in Idiopathic Focal Segmental Glomerulosclerosis with Nephrotic Syndrome

Table 3

Clinical, proteinuric, and histological parameters in patients who progressed to ESRD compared to patients who entered remission as first event.

	ESRD	Remission	𝑃
No. of patients	9	23
Age (yrs)	33 ± 21	41 ± 17	ns
Sex (M/F)	6/3	14/9	ns
Baseline eGFR mL/min/1.73 m^2	76 ± 30	85 ± 31	0.46
eGFR <60 mL/min/1.73 m^2	22%	26%	ns
BP ≥140/90 mmHg	56%	57%	ns
24 hP	14.1 ± 8.6	7.2 ± 3.0	0.003
UP/C	10486 ± 4100	5125 ± 3581	0.001
α2m/C	9.5 ± 6.4	1.2 ± 2.1	<0.001
FE IgG	0.234 ± 0.144	0.051 ± 0.050	<0.001
FE α1m	0.485 ± 0.204	0.210 ± 0.139	<0.001
Segmental sclerosis %	26 ± 13	18 ± 15	0.043
Global glom. sclerosis %	7 ± 13	5 ± 7	0.91
TID score	2.0 ± 2.1	1.6 ± 1.3	0.85
Time to ESRD (mths)	34 ± 35
Time to first remission (mths)		15 ± 19

eGFR: estimated GFR; BP: blood pressure; 24 hP: 24 hour proteinuria; UP/C: urinary protein/creatinine ratio; α2m/C: urinary α2-macroglobulin/creatinine ratio; FE IgG: fractional excretion of IgG; FE α1m: fractional excretion of α1-microglobulin; GGS: global glomerular sclerosis; TID score: tubulointerstitial damage score; SS: segmental sclerosis.