Table 2: List of studies describing the ROS-dependent effects of CNT.


SWCNT with 30% iron by massLipid peroxidation, reduced cell viability, and antioxidant reserve in human keratinocytes [170]
Acid treated MWCNTs with Co and NiDecreased cell viability, altered mitochondrial membrane potential in rat macrophages (NR8383) and human A549 lung cells[92]
SWCNTReduced cell viability and antioxidant reserve in rat lung epithelial cells[171]
SWCNTIncreased apoptosis, DNA damage, activated MAPKs, AP-1, NF-κB, and Akt in normal and malignant human mesothelial cells[93]
SWCNTReduced cell proliferation, activation of NF-κB in human keratinocytes[119]
Unpurified SWCNT (30% w/w iron)Activation of AP-1 and NF-κB, cytotoxicity, and proinflammatory response in  vitro and in  vivo [172]
Unpurified SWCNT (17.7% w/w iron)Lipid peroxidation, acute inflammatory response, decreased respiratory function in adult C57BL/6 mice[91]
Raw MWCNTDose-dependent cytotoxicity in RAW 264.7 macrophages and A549 cells: cell inflammation, membrane leakage, lipid peroxidation, and protein release[173]
MWCNTIncrease in cell permeability, cell migration, and endothelial permeability in human microvascular endothelial cells (HMVEC)[174]
SWCNTActivation of p38 MAPK in CNT mediated fibrogenic and angiogenic responses in  vitro in human lung fibroblasts[118]
MWCNTActivation of NF-κB, fibroblast-myofibroblast transformation, profibrogenic cytokine, and growth factor induction in  vitro (BEAS-2B, WI-38, and A549 cell lines)[18]