Evaluation of Adverse Effects of Mutein Forms of Recombinant Human Interferon Alpha-2b in Female Swiss Webster Mice

Table 2

Organ indices of female mice after a single dose of wild type rIFN-α2b or rIFN-α2bC₂DC₉₉D.

Organ	Control	Groups
		Wild type rIFN-α2b (D1)	rIFN-α2bC2DC99D (D1)	Wild type rIFN-α2b (D2)	rIFN-α2bC2DC99D (D2)	Wild type rIFN-α2b (D3)	rIFN-α2bC2DC99D (D3)
Heart	0.43 ± 0.04	0.45 ± 0.03	0.42 ± 0.02	0.43 ± 0.04	0.44 ± 0.04	0.43 ± 0.04	0.42 ± 0.04
Liver	4.91 ± 0.97	4.18 ± 1.81	4.57 ± 0.27	4.94 ± 0.50	5.53 ± 0.30	5.27 ± 0.50	5.05 ± 0.91
Kidney	1.07 ± 0.14	1.39 ± 0.09	1.17 ± 0.04	1.15 ± 0.11	1.12 ± 0.09	1.25 ± 0.15	1.16 ± 0.08
Limp	0.37 ± 0.14	0.36 ± 0.05	0.33 ± 0.06	0.34 ± 0.04	0.42 ± 0.13	0.63 ± 0.14	0.65 ± 0.28
Ovary-uterus	0.62 ± 0.21	0.73 ± 0.17	0.65 ± 0.11	0.63 ± 0.21	0.62 ± 0.15	0.62 ± 0.08	0.80 ± 0.26
Lung	0.54 ± 0.06	0.62 ± 0.09	0.54 ± 0.04	0.57 ± 0.12	0.58 ± 0.12	0.62 ± 0.06	0.59 ± 0.07